Inhibition of delta-aminolevulinic acid dehydratase by trichloroethylene
Koizumi, A; Fujita, H; Sadamoto, T; Yamamoto, M; Kumai, M; Ikeda, M
HERO ID
5471358
Reference Type
Journal Article
Year
1984
Language
English
PMID
| HERO ID | 5471358 |
|---|---|
| In Press | No |
| Year | 1984 |
| Title | Inhibition of delta-aminolevulinic acid dehydratase by trichloroethylene |
| Authors | Koizumi, A; Fujita, H; Sadamoto, T; Yamamoto, M; Kumai, M; Ikeda, M |
| Journal | Toxicology |
| Volume | 30 |
| Issue | 2 |
| Page Numbers | 93-102 |
| Abstract | Male Wistar rats (8 animals/group; 180-200 g) were exposed continuously to trichloroethylene (TRI) for 48 or 240 h or methylchloroform (1,1, 1-trichloroethane: MC for 48 h at 50, 400 and 800 ppm. The inhibition of delta-aminolevulinic acid dehydratase (ALA-D) was examined in liver, blood and bone marrow of naive and phenobarbital pretreated animals exposed to TRI. A clear cut dose-effect relationship between the exposure concentration or duration of exposure and the inhibition of ALA-D activity was seen for rats exposed to TRI. In addition to this finding, significant interaction between TRI exposure and phenobarbital treatment was observed in the inhibition of ALA-D in liver and blood. MC did not produce inhibition. Trichloroacetic acid and trichloroethanol failed to inhibit the ALA-D activity in vitro. It seems that a metabolite(s) of TRI other than the above 2 substances may play a role in the inhibition of ALA-D. The inhibition of ALA-D (38% or 48% of the control in liver or in blood, respectively) observed after the 240 h exposure at 400 ppm to TRI was accompanied by the significant elevation of delta-aminolevulinic acid synthase (186% of the control) in liver and the increase in excretion of delta-aminolevulinic acid in urine (142% of the control). This occurred without an apparent weight loss, liver injury or hematological changes. |
| Doi | 10.1016/0300-483x(84)90120-3 |
| Pmid | 6710543 |
| Wosid | WOS:A1984SN03700001 |
| Url | https://www.proquest.com/scholarly-journals/inhibition-delta-aminolevulinic-acid-dehydratase/docview/81005766/se-2?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Special character for delta. |
| Is Public | Yes |
| Language Text | English |
| Keyword | Trichloroethanes; 1,1,1-trichloroethane; 113C650IR1; Trichloroethylene; 290YE8AR51; Trichloroacetic Acid; 5V2JDO056X; Ethylene Chlorohydrin; 753N66IHAN; 2,2,2-trichloroethanol; AW835AJ62N; 5-Aminolevulinate Synthetase; EC 2.3.1.37; Porphobilinogen Synthase; EC 4.2.1.24; Phenobarbital; YQE403BP4D; Index Medicus; Ethylene Chlorohydrin -- pharmacology; 5-Aminolevulinate Synthetase -- metabolism; Trichloroethanes -- pharmacology; Rats, Inbred Strains; Trichloroacetic Acid -- pharmacology; Animals; Ethylene Chlorohydrin -- analogs & derivatives; Erythrocytes -- enzymology; Phenobarbital -- pharmacology; Liver -- enzymology; Bone Marrow -- enzymology; In Vitro Techniques; Trichloroethylene -- pharmacology; Porphobilinogen Synthase -- antagonists & inhibitors |
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