Chlorinated persistent organic pollutants and type 2 diabetes - A population-based study with pre- and post- diagnostic plasma samples
Tornevi, A; Sommar, J; Rantakokko, P; Åkesson, A; Donat-Vargas, C; Kiviranta, H; Rolandsson, O; Rylander, L; Wennberg, M; Bergdahl, IA
HERO ID
5432659
Reference Type
Journal Article
Year
2019
Language
English
PMID
| HERO ID | 5432659 |
|---|---|
| In Press | No |
| Year | 2019 |
| Title | Chlorinated persistent organic pollutants and type 2 diabetes - A population-based study with pre- and post- diagnostic plasma samples |
| Authors | Tornevi, A; Sommar, J; Rantakokko, P; Åkesson, A; Donat-Vargas, C; Kiviranta, H; Rolandsson, O; Rylander, L; Wennberg, M; Bergdahl, IA |
| Journal | Environmental Research |
| Volume | 174 |
| Issue | Elsevier |
| Page Numbers | 35-45 |
| Abstract | <strong>BACKGROUND: </strong>Persistent organic pollutants (POPs) have been associated with type 2 diabetes (T2D), but causality is uncertain.<br /><br /><strong>OBJECTIVE: </strong>Within longitudinal population-based data from northern Sweden, we assessed how POPs associated with T2D prospectively and cross-sectionally, and further investigated factors related to individual changes in POP concentrations.<br /><br /><strong>METHODS: </strong>For 129 case-controls pairs matched by age, sex and date of sampling, plasma concentrations of hexachlorobenzene (HCB), dichlorodiphenyl-dichloroethylene (p,p'-DDE), dioxin-like (DL) polychlorinated biphenyl congeners (PCB-118 and PCB-156), and non-dioxin like (NDL-PCB: PCB-74, -99, -138 -153, -170, -180, -183 and PCB-187) were analyzed twice (baseline and follow-up, 9-20 years apart). The cases received their T2D diagnose between baseline and follow-up. Prospective (using baseline data) and cross-sectional (using follow-up data) odds ratios (ORs) for T2D on lipid standardized POPs (HCB, p,p'-DDE, ∑DL-PCBs, ∑NDL-PCBs) were estimated using conditional logistic regression, adjusting for body mass index (BMI) and plasma lipids. The influence of BMI, weight-change, and plasma lipids on longitudinal changes in POP concentrations were evaluated among non-diabetic individuals (n = 306).<br /><br /><strong>RESULTS: </strong>POPs were associated with T2D in both the prospective and cross-sectional assessments. Of a standard deviation increase in POPs, prospective ORs ranged 1.42 (95% CI: 0.99, 2.06) for ∑NDL-PCBs to 1.55 (95% CI: 1.01, 2.38) for HCB (p < 0.05 only for HCB), and cross-sectional ORs ranged 1.62 (95% CI: 1.13; 2.32) for p,p'-DDE to 2.06 (95% CI: 1.29, 3.28) for ∑DL-PCBs (p < 0.05 for all POPs). In analyses of non-diabetic individuals, higher baseline BMI, decreased weight and decreased plasma lipid concentrations were associated with a slower decrease of POPs. Cases had, besides a higher BMI, reduced cholesterol and weight gain at follow-up compared to controls, which can explain the higher ORs in the cross-sectional assessments.<br /><br /><strong>DISCUSSION: </strong>The association between POPs and T2D was confirmed, but an indication that individuals body fat history might influence POP-T2D associations weakens the epidemiological support for a causal association. It also warrants studies based on other exposure metrics than biomonitoring. In addition, we note that a cross-sectional design overestimates the ORs if T2D cases have successfully intervened on weight and/or blood lipids, as changes in these factors cause changes in POPs. |
| Doi | 10.1016/j.envres.2019.04.017 |
| Pmid | 31029940 |
| Wosid | WOS:000470801100005 |
| Url | http://www.sciencedirect.com/science/article/pii/S0013935119302269 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Biomonitoring; Polychlorinated biphenyl congeners; Type 2 diabetes; Longitudinal data |