A proposed inhalation reference concentration for methanol
Starr, TB; Festa, JL
HERO ID
52598
Reference Type
Journal Article
Subtype
Review
Year
2003
Language
English
PMID
| HERO ID | 52598 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2003 |
| Title | A proposed inhalation reference concentration for methanol |
| Authors | Starr, TB; Festa, JL |
| Journal | Regulatory Toxicology and Pharmacology |
| Volume | 38 |
| Issue | 2 |
| Page Numbers | 224-231 |
| Abstract | A biologically based approach was taken to developing an inhalation Reference Concentration (RfC) for methanol, a high production volume chemical with many commercial applications, including use as an alternative fuel for motor vehicles and as a hydrogen source for fuel cells. Benchmark Dose methodology was applied to the most sensitive toxic endpoint for assessing potential health risks in humans, cervical rib malformation data obtained using CD-1 mice. The concentration of methanol in circulating blood was employed as the dose metric, and the maximum likelihood estimate of the blood methanol increment causing a 10% extra risk of these malformations, was 215.4 mg/L, with a lower 95% confidence bound of 97.4 mg/L. A "Reference Increment" for blood methanol was then determined by dividing this value by a 3-fold factor for residual pharmacodynamic uncertainty between species and a 10-fold factor for interindividual variation in human sensitivity to methanol. The resulting Reference Increment in blood methanol was then converted to an equivalent inhalation Reference Concentration with a physiologically based pharmacokinetic model evaluated for continuous exposure conditions. The resulting maximum likelihood estimate for the inhalation RfC was 298 mg/m3, with a 95% lower confidence bound of 135 mg/m3. |
| Pmid | 14550762 |
| Wosid | WOS:000186079800010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.Regul. Toxicol. Pharmacol. 38: 224-231. |
| Is Public | Yes |
| Language Text | English |
| Keyword | Abnormalities, Drug-Induced/etiology; Administration, Inhalation; Animals; Environmental Pollutants/administration & dosage/pharmacokinetics/toxicity; Female; Humans; Maternal-Fetal Exchange; Methanol/administration & dosage/pharmacokinetics/toxicity; Mice; Models, Animal; Pregnancy; Reference Values; Risk Assessment; Species Specificity; 0 (Environmental Pollutants); 67-56-1 (Methanol) |
| Is Qa | No |