Cancer epigenomics: DNA methylomes and histone-modification maps
Esteller, M
HERO ID
5077980
Reference Type
Journal Article
Subtype
Review
Year
2007
Language
English
PMID
| HERO ID | 5077980 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2007 |
| Title | Cancer epigenomics: DNA methylomes and histone-modification maps |
| Authors | Esteller, M |
| Journal | Nature Reviews. Genetics |
| Volume | 8 |
| Issue | 4 |
| Page Numbers | 286-298 |
| Abstract | An altered pattern of epigenetic modifications is central to many common human diseases, including cancer. Many studies have explored the mosaic patterns of DNA methylation and histone modification in cancer cells on a gene-by-gene basis; among their results has been the seminal finding of transcriptional silencing of tumour-suppressor genes by CpG-island-promoter hypermethylation. However, recent technological advances are now allowing cancer epigenetics to be studied genome-wide - an approach that has already begun to provide both biological insight and new avenues for translational research. It is time to 'upgrade' cancer epigenetics research and put together an ambitious plan to tackle the many unanswered questions in this field using epigenomics approaches. |
| Doi | 10.1038/nrg2005 |
| Pmid | 17339880 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Peer Review | Yes |