Pregnane X receptor and drug-induced liver injury
Wang, YM; Chai, SC; Brewer, CT; Chen, T
HERO ID
5077975
Reference Type
Journal Article
Subtype
Review
Year
2014
Language
English
PMID
| HERO ID | 5077975 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2014 |
| Title | Pregnane X receptor and drug-induced liver injury |
| Authors | Wang, YM; Chai, SC; Brewer, CT; Chen, T |
| Journal | Expert Opinion on Drug Metabolism & Toxicology |
| Volume | 10 |
| Issue | 11 |
| Page Numbers | 1521-1532 |
| Abstract | <strong>INTRODUCTION: </strong>The liver plays a central role in transforming and clearing foreign substances. The continuous exposure of the liver to xenobiotics sometimes leads to impaired liver function, referred to as drug-induced liver injury (DILI). The pregnane X receptor (PXR) tightly regulates the expression of genes in the hepatic drug-clearance system and its undesired activation plays a role in DILI.<br /><br /><strong>AREAS COVERED: </strong>This review focuses on the recent progress in understanding PXR-mediated DILI and highlights the efforts made to assess and manage PXR-mediated DILI during drug development.<br /><br /><strong>EXPERT OPINION: </strong>Future efforts are needed to further elucidate the mechanisms of PXR-mediated liver injury, including the epigenetic regulation and polymorphisms of PXR. Novel in vitro models containing functional PXR could improve our ability to predict and assess DILI during drug development. PXR inhibitors may provide chemical tools to validate the potential of PXR as a therapeutic target and to develop drugs to be used in the clinic to manage PXR-mediated DILI. |
| Doi | 10.1517/17425255.2014.963555 |
| Pmid | 25252616 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | PMC access to author manuscript: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198438/ |
| Is Public | Yes |
| Language Text | English |