Acute toxicity of vanadium compounds in rats and mice
Llobet, JM; Domingo, JL
HERO ID
5058589
Reference Type
Journal Article
Year
1984
Language
English
PMID
| HERO ID | 5058589 |
|---|---|
| In Press | No |
| Year | 1984 |
| Title | Acute toxicity of vanadium compounds in rats and mice |
| Authors | Llobet, JM; Domingo, JL |
| Journal | Toxicology Letters |
| Volume | 23 |
| Issue | 2 |
| Page Numbers | 227-231 |
| Abstract | Sodium metavanadate (NaVO3) and vanadyl sulphate pentahydrate (VOSO4 X 5H2O) were administered to rats and mice. The following LD50 (14-day) were determined: NaVO3, 98.0 mg/kg (rats) and 74.6 mg/kg (mice) when given orally, and 18.4 mg/kg (rats) and 35.9 mg/kg (mice) when given i.p.; VOSO4 X 5H2O, 448.0 mg/kg (rats) and 467.2 mg/kg (mice) when given orally, and 74.1 mg/kg (rats) and 113.0 mg/kg (mice) when given i.p. The majority of deaths occurred during the first 24 h. The clinical and physical signs appearing after the intoxication include irregular respiration, diarrhea, ataxia and paralysis of the hind legs. These signs disappeared for the most part after 48 h, which suggests a quick elimination of vanadium. |
| Doi | 10.1016/0378-4274(84)90131-0 |
| Pmid | 6334379 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |