Effects of ambient air pollution on incident Parkinson's disease in Ontario, 2001 to 2013: a population-based cohort study
Shin, S; Burnett, RT; Kwong, JC; Hystad, P; van Donkelaar, A; Brook, JR; Copes, R; Tu, K; Goldberg, MS; Villeneuve, PJ; Martin, RV; Murray, BJ; Wilton, AS; Kopp, A; Chen, H
HERO ID
5017389
Reference Type
Journal Article
Year
2018
Language
English
PMID
| HERO ID | 5017389 |
|---|---|
| In Press | No |
| Year | 2018 |
| Title | Effects of ambient air pollution on incident Parkinson's disease in Ontario, 2001 to 2013: a population-based cohort study |
| Authors | Shin, S; Burnett, RT; Kwong, JC; Hystad, P; van Donkelaar, A; Brook, JR; Copes, R; Tu, K; Goldberg, MS; Villeneuve, PJ; Martin, RV; Murray, BJ; Wilton, AS; Kopp, A; Chen, H |
| Journal | International Journal of Epidemiology |
| Volume | 47 |
| Issue | 6 |
| Page Numbers | 2038-2048 |
| Abstract | <strong>Background: </strong>Despite recent studies linking air pollution to neurodegenerative illness, evidence relating air pollution and Parkinson's disease (PD) remains scarce. We conducted a population-based cohort study in Ontario, Canada, to determine the association between air pollution and incident PD.<br /><br /><strong>Methods: </strong>Using health administrative databases, we identified all adults aged 55-85 years, free of PD, and who lived in Ontario on 1 April 2001 (∼2.2 million). Individuals were followed up until 31 March 2013. We derived long-term average exposures to fine particulate matter (particles ≤2.5 µm in diameter, or PM2.5), nitrogen dioxide (NO2) and ozone from satellite-based estimates, land-use regression models and optimal interpolation methods, respectively. Using 2-year lags in exposures, we linked these estimates to individuals' annual postal codes from 1994 (7 years before cohort inception). We applied spatial random-effects Cox proportional hazards models, adjusting for individual- and area-level characteristics. We also performed sensitivity analyses, such as considering longer lags in exposures and stratifying by selected characteristics.<br /><br /><strong>Results: </strong>During the study period, we identified 38 745 newly diagnosed cases of PD. Each interquartile increment (3.8 µg/m3) of PM2.5 was associated with a 4% increase in incident PD (95% confidence interval, 1.01-1.08) after adjusting for various covariates. We also found positive associations for NO2 and ozone [hazard ratios (HRs) ranged from 1.03 to 1.04]. The associations for all exposures were unaltered with various sensitivity analyses except for considering longer lags, which somewhat attenuated the estimates, particularly for NO2 and ozone.<br /><br /><strong>Conclusions: </strong>Exposure to air pollution, especially PM2.5, was found to be related to incident PD. |
| Doi | 10.1093/ije/dyy172 |
| Pmid | 30124852 |
| Wosid | WOS:000456664500035 |
| Url | https://academic.oup.com/ije/article/47/6/2038/5075193 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Parkinson's disease; neurodegenerative diseases; air pollution; incidence |
| Is Peer Review | Yes |