1-butoxypropan-2-ol: Acute toxicity: Oral: 001 Key | experimental result
HERO ID
5015980
Reference Type
Technical Report
Year
1987
Language
English
| HERO ID | 5015980 |
|---|---|
| Year | 1987 |
| Title | 1-butoxypropan-2-ol: Acute toxicity: Oral: 001 Key | experimental result |
| Authoring Organization | European Chemicals Agency |
| Publisher Text | European Chemicals Agency |
| City | Helsinki, Finland |
| Abstract | Three groups of Wistar rats (5/sex/dose level) received single oral doses of 1800, 2400, or 3200 mg/kg propylene glycol n-butyl ether (PnB), administered undiluted using a stainless steel stomach cannula attached to a syringe. No rats died from a dose of 1800 mg/kg PnB. One female died after a dose of 2400 mg/kg. Four females and one male died at 3200 mg/kg. The calculated oral LD50 for males alone was 5500 mg/kg (no 95% confidence limits), for females alone was 2700 mg/kg (95% CL: 2400 - 3600 mg/kg), and for both sexes combined was 3300 (95% CL: 2800 - 4500 mg/kg). All deaths occurred within one day of dosing. Adverse signs included weight loss, lethargy, coma, hypopnea, gasping, and dacryorrhea. Surviving rats showed no adverse signs by day 2. At necropsy, surviving rats showed no grossly observable lesions. Rats dying from treatment exhibited hemorrhage of the stomach and small intestine, bloody content of the small intestine and bladder, yellow liquid within the small intestine, and hyperemia of the bladder. |
| Url | https://echa.europa.eu/registration-dossier/-/registered-dossier/14287/7/3/2/?documentUUID=b57a995b-6395-4a3e-b9f4-69be78883507 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECHA Registered Dossier 14287 |
| Is Public | Yes |
| Language Text | English |