Arthritogenicity of wax D from various mycobacteria related to oil vehicle composition and to the combination with poly I:C, cord factor and acetylated wax D
Kohasi, O; Pearson, CM; Koga, T
| HERO ID | 4968893 |
|---|---|
| In Press | No |
| Year | 1977 |
| Title | Arthritogenicity of wax D from various mycobacteria related to oil vehicle composition and to the combination with poly I:C, cord factor and acetylated wax D |
| Authors | Kohasi, O; Pearson, CM; Koga, T |
| Journal | International Archives of Allergy and Applied Immunology |
| Volume | 53 |
| Issue | 4 |
| Page Numbers | 357-365 |
| Abstract | Most of wax D (peptidoglycolipid) used here appeared to be ineffective for production of arthritis when given in a water-in-oil emulsion, while the same wax D in squalane was very effective for production of arthritis. Arlacel A as an emulsifier appeared to suppress the arthritogenicity of wax D in squalane, probably through some interaction with the arthritogenic portion of wax D. Poly 1:C seemed to remarkedly enhance the arthritogenicity of wax D, even in water-in-oil emulsion. Acetylated wax D and cord factor (trehalsoe-dimycolate) were much less effective than poly 1:C. Delayed skin hypersensitivity to PPD, peptidoglycan and poly 1:C was also remarkedly affected by oil composition. However, there was no correlation between these delayed hypersensitivities and development of arthritis. |
| Pmid | 852904 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |