Adjuvant formulations and their mode of action
Allison, AC; Byars, NE
| HERO ID | 4968691 |
|---|---|
| In Press | No |
| Year | 1990 |
| Title | Adjuvant formulations and their mode of action |
| Authors | Allison, AC; Byars, NE |
| Journal | Seminars in Immunology |
| Volume | 2 |
| Issue | 5 |
| Page Numbers | 369-374 |
| Abstract | We have developed an adjuvant formulation (SAF) consisting of a synthetic muramyl dipeptide analogue (N-acetylmuramyl-L-threonyl-D-isoglutamine) in a squalane-Pluronic polymer emulsion. Used with a variety of antigens SAF elicits cell-mediated immunity and antibodies of protective isotypes (IgG2a in the mouse). SAF augments responses to influenza virus haemagglutinin and hepatitis B virus surface antigen. Vaccines using SAF have protected guinea pigs against genital herpes simplex virus infections and subhuman primates against Epstein-Barr virus and simian immunodeficiency virus infections. Properties of SAF are compared with those of other adjuvants, including lipopolysaccharide analogs, ISCOMs and liposomes. |
| Pmid | 1966859 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |