Validation of a first-generation Epstein-Barr virus vaccine preparation suitable for human use
Morgan, AJ; Allison, AC; Finerty, S; Scullion, FT; Byars, NE; Epstein, MA
| HERO ID | 4968684 |
|---|---|
| In Press | No |
| Year | 1989 |
| Title | Validation of a first-generation Epstein-Barr virus vaccine preparation suitable for human use |
| Authors | Morgan, AJ; Allison, AC; Finerty, S; Scullion, FT; Byars, NE; Epstein, MA |
| Journal | Journal of Medical Virology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 74-78 |
| Abstract | The efficacy of a new vaccine preparation against Epstein-Barr (EB) virus was investigated in cotton-top tamarins. The vaccine consists of fast protein liquid chromatography-purified EB virus membrane antigen glycoprotein of 340 Kd (MA gp340) mixed with a synthetic muramyl dipeptide adjuvant emulsified in squalane containing a pluronic polymer; it is suitable for both scaled-up batch production and eventual administration to man. Vaccinated tamarins rapidly developed ELISA detectable high titre antibodies to MA gp340, and their sera became strongly EB virus-neutralising. After challenge with a massive 100% carcinogenic dose of EB virus, the vaccinated tamarins had a strikingly low level of circulating EB virus-carrying mononuclear cells, in contrast to a control animal, and remained entirely free of tumours. This first-generation vaccine has thus been validated in experimental animals and the way opened for a phase I human trial. |
| Pmid | 2555448 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
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