A histopathological evaluation of the safety of squalane fluid applied subcutaneously
Kawakami, T; Takei, N; Antoh, M; Hasegawa, H; Kise, T; Eda, S
| HERO ID | 4968649 |
|---|---|
| In Press | No |
| Year | 1995 |
| Title | A histopathological evaluation of the safety of squalane fluid applied subcutaneously |
| Authors | Kawakami, T; Takei, N; Antoh, M; Hasegawa, H; Kise, T; Eda, S |
| Journal | Medical Science Research |
| Volume | 23 |
| Issue | 8 (Aug 1995) |
| Page Numbers | 521-523 |
| Abstract | Squalane is obtained by hydrogenation from squalene, an unsaturated terpene hydrocarbon found mainly in shark liver oil. It is a very stable liquid, and has a remarkably low capacity to irritate the skin. Squalane is used as an important component in various kinds of cosmetics and has a considerably beneficial effect on faecal excretion of the highly toxic 2, 3, 4, 7, 8-pentachlorodibenzofuran (PenCDF). The distribution, excretion and subacute toxicity of squalane after oral administration has already been examined. We considered that squalane, applied subcutaneously, might be an effective carrier of drugs. Furthermore, we found an application of squalane as a carrier of bone morphogenetic protein (BMP). As there were no data on the tissue reaction to squalane administered subcutaneously, we decided to make a histopathological evaluation of squalane fluid in vivo (DBO). |
| Wosid | WOS:A1995RR05300005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | toxicity; histopathology |