Clinical evaluation of a new sugar coated potassium chloride supplement
Hutchison, JC
HERO ID
4947804
Reference Type
Journal Article
Year
1974
Language
English
| HERO ID | 4947804 |
|---|---|
| In Press | No |
| Year | 1974 |
| Title | Clinical evaluation of a new sugar coated potassium chloride supplement |
| Authors | Hutchison, JC |
| Journal | Journal of Clinical Pharmacology |
| Volume | 14 |
| Issue | 11 (Nov-Dec) |
| Page Numbers | 624-629 |
| Abstract | IPA COPYRIGHT: ASHP Potassium chloride, as a sugar coated tablet embedded in a wax matrix (Slow-K) and potassium gluconate solution (Kaon), were compared in 20 outpatients suffering from hypertension and receiving potassium wasting diuretics, capable of producing hypokalemia. The patients were randomly divided into 2 groups of 10 each. One group received the solution for 4 weeks (40 meq potassium/day) and was then switched to the tablet (48 meq/day) for another 4 weeks. The second group began treatment with the tablet, crossing over to the solution after 4 weeks. The patients completed a self rating questionnaire on preference and GI side effects after each 4 week period. Both medications appeared equally effective in maintaining serum levels of potassium and chloride. GI side effects were not severe with either preparation. No gross or occult blood was detected in the stools for any patient. Patient preferences favored the tablet. Ninety-five per cent of the subjects found the tablets more acceptable than the liquid, and 90% found them more convenient. Based upon these findings, the tablet appears to possess decided clinical advantage over a solution with respect to patient compliance and acceptance. |
| Doi | 10.1002/j.1552-4604.1974.tb01383.x |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |