[Pharmacokinetics of a fluoride-calcium preparation for the treatment of osteoporosis]
Fuchs, C; Haase, W; Maurer, H
HERO ID
4947661
Reference Type
Journal Article
Year
1984
Language
German
PMID
| HERO ID | 4947661 |
|---|---|
| In Press | No |
| Year | 1984 |
| Title | [Pharmacokinetics of a fluoride-calcium preparation for the treatment of osteoporosis] |
| Authors | Fuchs, C; Haase, W; Maurer, H |
| Journal | Arzneimittel-Forschung |
| Volume | 34 |
| Issue | 7 |
| Page Numbers | 832-835 |
| Abstract | The pharmacokinetics of fluoride and calcium were studied after administration of a combined fluoride and calcium preparation (Tridin) (1, 2 and 3 tablets) in 9 healthy male volunteers, using a cross-over study design. The total estimation of the pharmacokinetic data was performed by a simultaneous curve fitting to all single values, using a direct search procedure based on an open two-compartment model and three-compartment model, respectively. Maximum plasma concentrations and areas under the curve are proportional to the dose administered. Inter-subject variations are comparatively small, computerized multiple dose simulation for 3 days does not show any cumulation. The data fit the two-compartment model and the three-compartment model as well. The behaviour of the calcium concentrations reflects the immediate response of calcium homeostasis: plasma calcium concentrations are not affected. |
| Pmid | 6541921 |
| Wosid | WOS:A1984TA60400022 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | German |