Chemical stability and degradation mechanisms of ferulic acid (F.A) within various cosmetic formulations
Wang, QJ; Gao, X; Gong, H; Lin, XR; Saint-Leger, D; Senee, J
| HERO ID | 4947155 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | Chemical stability and degradation mechanisms of ferulic acid (F.A) within various cosmetic formulations |
| Authors | Wang, QJ; Gao, X; Gong, H; Lin, XR; Saint-Leger, D; Senee, J |
| Journal | Journal of Cosmetic Science |
| Volume | 62 |
| Issue | 5 |
| Page Numbers | 483-503 |
| Abstract | Ferulic acid (F.A) receives significant interest in the beauty industry with regard to its skin-whitening and anti-oxidant properties. However, its use in cosmetics is limited due to pH- and temperature-related instabilities. In this study, we investigated the stability of F.A in eight different prototype formulae. The results confirmed that in our conditions the stability of F.A is pH- and temperature-related. Additionally, the nature of the solvent dipropylene glycol (DPPG) showed a capacity to stabilize F.A. A series of experiments was further planned for studying the mechanism of degradation of F.A. In a prototype of a cosmetic medium, F.A degrades first through a decarboxylation step, leading to 4-hydroxy-3-methoxystyrene (PVG). Further, F.A and PVG are both involved in an additional reaction, resulting in the trans-conjugation dimer of PVG. The consequences of these results in formulating F.A are discussed. |
| Pmid | 22152493 |
| Wosid | WOS:000209067000003 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |