Nonenzymatic determination of glucose at near neutral pH values based on the use of nafion and platinum black coated microneedle electrode array
Chinnadayyala, SR; Park, I; Cho, S
| HERO ID | 4946816 |
|---|---|
| In Press | No |
| Year | 2018 |
| Title | Nonenzymatic determination of glucose at near neutral pH values based on the use of nafion and platinum black coated microneedle electrode array |
| Authors | Chinnadayyala, SR; Park, I; Cho, S |
| Journal | Microchimica Acta |
| Volume | 185 |
| Issue | 5 |
| Page Numbers | 250 |
| Abstract | The authors report on a microneedle-based amperometric nonenzymatic glucose sensor for painless and continuous monitoring of glucose. It consists of 3 × 5 sharp stainless steel microneedles micromachined from a stainless steel substrate. The microneedles are 600 and 100 μm in height and width, respectively. Nafion and platinum black were sequentially coated onto the tip of gold-coated microneedles and used for nonenzymatic (direct) sensing of glucose. Attractive features of the modified microneedle electrode include (a) a low working potential (+0.12 V vs. Ag/AgCl), (b) a linear response in the physiologically relevant range (1-40 mM), (c) a sensitivity as high as 175 μA mM-1 cm-2, (d) a 23 μM detection limit, and (e) a response time of 2 s. The sensor also exhibits good reproducibility and stability. The sensor is selective for glucose even in the presence of 10-fold higher concentrations of ascorbic acid, lactic acid, dopamine, uric acid, and acetaminophen. Graphical abstract Schematic representation of the fabrication sequence for a nonenzymatic electrochemical glucose sensor using Nafion and platinum black coated microneedle electrode array. The sensor is based on measuring the faradaic current at +0.12 V vs. Ag/AgCl by the direct electrochemical oxidation of glucose to gluconic acid on the surface of a Pt black sensing layer. |
| Doi | 10.1007/s00604-018-2770-1 |
| Pmid | 29627889 |
| Wosid | WOS:000431462800002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |