Involvement of chloride channels in progesterone production during meiotic maturation of follicle-enclosed oocytes of Rana temporaria and Xenopus laevis
Skoblina, MN; Huhtaniemi, I
HERO ID
4942584
Reference Type
Journal Article
Year
1997
Language
English
PMID
| HERO ID | 4942584 |
|---|---|
| In Press | No |
| Year | 1997 |
| Title | Involvement of chloride channels in progesterone production during meiotic maturation of follicle-enclosed oocytes of Rana temporaria and Xenopus laevis |
| Authors | Skoblina, MN; Huhtaniemi, I |
| Journal | Journal of Experimental Zoology |
| Volume | 278 |
| Issue | 6 |
| Page Numbers | 422-428 |
| Abstract | The chloride channel blockers SITS (4-acetamido-4'-isothiocyanostibene-2,2'-disulphonic acid) and DIDS (4,4'-diisothiocyanostilbene-2,2'-disulphonic acid) markedly suppressed progesterone production in the Rana temporaria and Xenopus laevis follicle-enclosed oocytes and oocyte maturation stimulated by the homologous pituitary suspension and hCG, respectively. Inhibition was dose-dependent and decreased with the increase of the hormone concentration. SITS did not affect progesterone production in the R. temporaria follicle-enclosed oocytes stimulated by dbcAMP. Substitution of sodium chloride for equimolar concentrations of sodium gluconate, methanesulfonate, glutamate, or formate significantly potentiated the gonadotropin-stimulated progesterone production and oocyte maturation in the both species. Possible involvement of chloride channels in progesterone production by the gonadotropin-stimulated amphibian follicle-enclosed oocytes is discussed. (C) 1997 Wiley-Liss, Inc. |
| Doi | 10.1002/(SICI)1097-010X(19970815)278:6<422::AID-JEZ10>3.0.CO;2-0 |
| Pmid | 9262009 |
| Wosid | WOS:A1997XP43300011 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |