Final report on the safety assessment of butylene glycol, hexylene glycol, ethoxydiglycol, and dipropylene glycol
HERO ID
4941420
Reference Type
Journal Article
Year
1985
Language
English
| HERO ID | 4941420 |
|---|---|
| In Press | No |
| Year | 1985 |
| Title | Final report on the safety assessment of butylene glycol, hexylene glycol, ethoxydiglycol, and dipropylene glycol |
| Authoring Organization | Cosmetic Ingredient Review |
| Journal | Journal of the American College of Toxicology |
| Volume | 4 |
| Issue | 5 |
| Page Numbers | 223-248 |
| Abstract | Butylene Glycol, Hexylene Glycol, Ethoxydiglycol, and Dipropylene Glycol are viscous liquids used in the cosmetic industry as humectants, emulsifiers, plasticizers, and solvents. The results of acute, subchronic, and chronic oral toxicity studies using a variety of animal species indicate low order of toxicity for the Glycols. Butylene Glycol, Ethoxydiglycol, and Dipropylene Glycol caused minimal to mild irritation of rabbit skin, whereas Hexylene Glycol was moderately irritating. The Glycols produced mild to severe ocular irritation when tested in rabbit, with Hexylene Glycol producing the most severe irritation. Human skin patch tests on undiluted Butylene Glycol and undiluted Hexylene Glycol produced a very low order of primary skin irritation. A repeated insult patch test on Butylene Glycol produced no evidence of skin sensitization. It is concluded the Butylene Glycol, Hexylene Glycol, Ethoxydiglycol, and Dipropylene Glycol are safe as presently used in cosmetics. |
| Wosid | WOS:A1985AVY4100009 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | cosmetics industry; risk assessment; cosmetics; skin tests; man |