Synthesis of 2-[H-2]-2-(1-methylalkyl)succinic acids
Bian, XinYu; Mbadinga, SM; Yang, ShiZ; Ye, RuQ; Gu, JiD; Mu, BoZ
| HERO ID | 4936110 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | Synthesis of 2-[H-2]-2-(1-methylalkyl)succinic acids |
| Authors | Bian, XinYu; Mbadinga, SM; Yang, ShiZ; Ye, RuQ; Gu, JiD; Mu, BoZ |
| Journal | Chinese Chemical Letters |
| Volume | 26 |
| Issue | 5 |
| Page Numbers | 619-622 |
| Abstract | We describe a specific procedure for the synthesis of deuterium-labelled 2-(1-methylalkyl)succinate established via alkylation of diethyl malonate, Krapcho decarboxylation reaction with D2O and hydrolysis reaction. Two novel compounds, 2-[H-2]-2-ethylsuccinic acid and 2-(H-2-2-(1-methylheptyl)succinic acid were prepared via this synthetic route and characterized by mass spectrometry and H-1 NMR. The results showed that the 2-(1-methylalkyl)succinic acids were deuterated at the beta-position, which is considered as an important reaction centre in the anaerobic degradation of n-alkanes. (C) 2015 Chinese Chemical Society and Institute of Materia Medics, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| Doi | 10.1016/j.cclet.2015.01.010 |
| Wosid | WOS:000356116300028 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Deuterium-labelled biomarkers; 2-(1-Methylalkyl)succinates; Fumarate addition; Anaerobic degradation of alkanes |