Palladium-Catalyzed Asymmetric Benzylic Substitution of Secondary Benzyl Carbonates with Nitrogen and Oxygen Nucleophiles
Najib, A; Hirano, K; Miura, M
| HERO ID | 4936024 |
|---|---|
| In Press | No |
| Year | 2017 |
| Title | Palladium-Catalyzed Asymmetric Benzylic Substitution of Secondary Benzyl Carbonates with Nitrogen and Oxygen Nucleophiles |
| Authors | Najib, A; Hirano, K; Miura, M |
| Journal | Organic Letters |
| Volume | 19 |
| Issue | 9 |
| Page Numbers | 2438-2441 |
| Abstract | A Pd/(R)-BINAP-catalyzed asymmetric benzylic substitution of secondary benzyl carbonates with amides and amines proceeds to form the corresponding optically active benzylamines in good yields with a high enantiomeric ratio. The reaction occurs in a dynamic kinetic asymmetric transformation (DYKAT) manner. Additionally, the asymmetric Pd catalysis can also be applicable to phenol nucleophiles, thus delivering chiral ethers with acceptable yields and enantioselectivity. |
| Doi | 10.1021/acs.orglett.7b01022 |
| Pmid | 28447794 |
| Wosid | WOS:000401044500061 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |