Synthesis of carbon-14 labelled 2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxybut-1-yl)purine (SK 1875), a potential prodrug of penciclovir
Kim, DK; Lee, J; Kim, Y; Lee, N; Kim, YW; Chang, KY; Kim, JS; Lee, K; Kim, KH
| HERO ID | 4935855 |
|---|---|
| In Press | No |
| Year | 1999 |
| Title | Synthesis of carbon-14 labelled 2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxybut-1-yl)purine (SK 1875), a potential prodrug of penciclovir |
| Authors | Kim, DK; Lee, J; Kim, Y; Lee, N; Kim, YW; Chang, KY; Kim, JS; Lee, K; Kim, KH |
| Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume | 42 |
| Issue | 6 |
| Page Numbers | 597-604 |
| Abstract | The synthesis of C-14-2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxy-but-1-yl)purine from [1-C-14] diethyl malonate is described. The overall radiochemical yield of the product in a nine-step sequence was 16.1%, and the compound's radiochemical purity was 98.5%. |
| Doi | 10.1002/(SICI)1099-1344(199906)42:6<597::AID-JLCR220>3.0.CO;2-# |
| Wosid | WOS:000080778800009 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | 2-amino-9-(3-hydroxy[C-14]methyl-4-isopropoxycarbonyloxybut-1-yl)purine; SK1875[C-14]; antiviral agent; radiosynthesis |