SYNTHESES OF 5-FLUORO-D/L-DOPA AND [F-18] 5-FLUORO-L-DOPA
Argentini, M; Wiese, C; Weinreich, R
| HERO ID | 4935824 |
|---|---|
| In Press | No |
| Year | 1994 |
| Title | SYNTHESES OF 5-FLUORO-D/L-DOPA AND [F-18] 5-FLUORO-L-DOPA |
| Authors | Argentini, M; Wiese, C; Weinreich, R |
| Journal | Journal of Fluorine Chemistry |
| Volume | 68 |
| Issue | 2 |
| Page Numbers | 141-144 |
| Abstract | This paper describes the synthesis of 5-fluoro-D/L-dopa and the corresponding [F-18]5-fluoro-L-dopa starting from 5-nitrovanillin via malonic ester synthesis, the Balz-Schiemann reaction and the separation of the racemic mixture [F-18]5-fluoro-D/L-dopa with a chiral HPLC system. The inactive 5-fluoro-D/L-dopa was obtained in an eight-step synthesis with an overall yield of 10%. For a reliable synthesis, the nitro group was reduced with hydrazine hydrate and ruthenium on charcoal. |
| Doi | 10.1016/0022-1139(93)03032-H |
| Wosid | WOS:A1994NZ48600005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |