Mixture experiments with the oil phase of parenteral emulsions
Jumaa, M; Kleinebudde, P; Müller, BW
| HERO ID | 4932692 |
|---|---|
| In Press | No |
| Year | 1998 |
| Title | Mixture experiments with the oil phase of parenteral emulsions |
| Authors | Jumaa, M; Kleinebudde, P; Müller, BW |
| Journal | European Journal of Pharmaceutics and Biopharmaceutics |
| Volume | 46 |
| Issue | 2 |
| Page Numbers | 161-167 |
| Abstract | The effects of the oil phase as a mixture (binary, ternary) on the emulsion droplet size were investigated. The binary trials were performed with the aid of simplex lattice design with constraints. Droplet diameter was evaluated in terms of the oil phase viscosity and the interfacial tension between oil phase and the aqueous phase. As a result it could be shown that increasing the oil phase viscosity as a function of castor oil concentration led to a greater increase in particle size. At the same time, decreasing the interfacial tension of the oil phase as a function of oleic acid or oleic alcohol was shown to have a negligible effect on the particle size of the dispersed phase. A further aim was to find out a formulation by using a ternary oil phase resulting in a stable emulsion which could pass the autoclaving process. It was ascertained that oleic acid as a part of the oil phase led to proper formulation showing a satisfactory stability. |
| Doi | 10.1016/S0939-6411(97)00170-7 |
| Pmid | 9795041 |
| Wosid | WOS:000076839100004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | parenteral emulsions; oil phase mixture; viscosity; interfacial tension; lattice design |