Serum Polybrominated Biphenyls (PBBs) and Polychlorinated Biphenyls (PCBs) and Thyroid Function among Michigan Adults Several Decades after the 1973-1974 PBB Contamination of Livestock Feed
Jacobson, MH; Darrow, LA; Barr, DB; Howards, PP; Lyles, RH; Terrell, ML; Smith, AK; Conneely, KN; Marder, ME; Marcus, M
HERO ID
4857702
Reference Type
Journal Article
Year
2017
Language
English
PMID
| HERO ID | 4857702 |
|---|---|
| In Press | No |
| Year | 2017 |
| Title | Serum Polybrominated Biphenyls (PBBs) and Polychlorinated Biphenyls (PCBs) and Thyroid Function among Michigan Adults Several Decades after the 1973-1974 PBB Contamination of Livestock Feed |
| Authors | Jacobson, MH; Darrow, LA; Barr, DB; Howards, PP; Lyles, RH; Terrell, ML; Smith, AK; Conneely, KN; Marder, ME; Marcus, M |
| Journal | Environmental Health Perspectives |
| Volume | 125 |
| Issue | 9 |
| Page Numbers | 097020 |
| Abstract | <strong>BACKGROUND: </strong>In 1973-1974, Michigan residents were exposed to polybrominated biphenyls (PBBs) through an accidental contamination of the food supply. Residents were enrolled in a registry assembled after the incident, and they and their children participated in follow-up studies to assess subsequent health outcomes.<br /><br /><strong>OBJECTIVES: </strong>We evaluated associations between serum PBBs and polychlorinated biphenyls (PCBs) and markers of thyroid function among Michigan adults.<br /><br /><strong>METHODS: </strong>Serum concentrations of four PBB and four PCB congeners were measured at least once in 753 adults, including 79 women who participated in a 2004-2006 study and 683 women and men with follow-up during 2012-2015. Participants completed questionnaires on health conditions (including physician-diagnosed thyroid disease), behaviors, and demographics. Thyroid hormones were measured in a subset without thyroid disease (n=551). In multivariable linear regression models, PBB and PCB congener concentrations, on both the volume (nanogram/milliliter) and lipid (nanogram/gram lipid) basis, were assessed in relation to thyroid hormones. Logistic regression models were used to estimate associations between serum PBBs and PCBs and thyroid disease.<br /><br /><strong>RESULTS: </strong>Thyroid disease was common (18% overall; 25% among women). Among women, all odds ratios (ORs) for PBB-153 and thyroid disease were positive for quintiles above the reference level, but estimates were imprecise and were without a monotonic increase. For an interquartile range (IQR) increase in PBB-153 (0.43 ng/mL), the OR (any thyroid disease)=1.12; (95% CI: 0.83, 1.52) (n=105 cases); for hypothyroidism, OR=1.35 (95% CI: 0.86, 2.13) (n=49 cases). There were 21 cases of thyroid disease in men [OR=0.69 (95% CI: 0.33); 1.44 for an IQR increase (0.75 ng/mL) in serum PBB-153]. PCB congeners were statistically significantly associated with greater total and free thyroxine and total triiodothyronine among women and with total and free triiodothyronine among men in lipid-standardized models.<br /><br /><strong>CONCLUSIONS: </strong>We found some evidence to support associations of PBBs and PCBs with thyroid disease and thyroid hormone levels. https://doi.org/10.1289/EHP1302. |
| Doi | 10.1289/EHP1302 |
| Pmid | 28953452 |
| Wosid | WOS:000413792800030 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Michigan; United States--US; Accidental contamination; Hormones; Feeds; Contamination; PCB compounds; Food contamination & poisoning; Models; Demographics; Thyroid gland; Regression analysis; Regression models; Hypothyroidism; Children; Thyroid; Animal feeds; Polychlorinated biphenyls--PCB; Polychlorinated biphenyls; Polybrominated biphenyls; Thyroxine; PCB; Thyroid hormones; Men; Livestock feed; Livestock; Health risk assessment; Adults; Food supply; Demography; Triiodothyronine; Food contamination; Congeners |
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