Chemical test rule data. Sodium glucoheptonate, acute oral toxicity in the rate - up-and-down procedure.
HERO ID
4851345
Reference Type
Technical Report
Year
2013
Language
English
| HERO ID | 4851345 |
|---|---|
| Year | 2013 |
| Title | Chemical test rule data. Sodium glucoheptonate, acute oral toxicity in the rate - up-and-down procedure. |
| Authoring Organization | Harlan Laboratories |
| Publisher Text | Harcros Chemicals Inc |
| City | Dalton, GA |
| Abstract | Introduction: The study was performed to assess the acute oral toxicity of the test item following a single oral administration in the Wistar strain rat. The method was designed to be compatible with the following: • OECD Guidelines for the Testing of Chemicals No. 425 "Acute Oral Toxicity - Up-and-Down-Procedure (UDP)" (adopted 03 October 2008) Method: A total of five female animals were dosed individually in sequence with sufficient time (at least 48 hours) between each animal, at dose levels of 354, 1112 or 4040 mg/kg bodyweight (equivalent to 175, 550 and 2000 mg active ingredient/kg bodyweight, respectively). The test item was administered orally undiluted at dose levels of 1112 and 4040 mg/kg bodyweight (equivalent to 550 and 2000 mg active ingredient/kg bodyweight, respectively) and as a solution in distilled water at a dose level of 354 mg/kg bodyweight (equivalent to 175 mg active ingredient/kg bodyweight). Clinical signs and bodyweight development were monitored during the study. AH animals were subjected to gross necropsy. Mortality. There were no deaths. Clinical Observations: Hunched posture was noted in the animal treated at a dose level of 1112 mg/kg (equivalent to 550 mg active ingredient/kg bodyweight). No other signs of systemic toxicity were noted. Bodyweight: Animals showed expected gains in bodyweight over the study period, except for one animal treated at a dose level of 4040 mg/kg (equivalent to 2000 mg active ingredient/kg bodyweight) which showed expected gain in bodyweight during the first week but no gain in bodyweight during the second week. Necropsy: No abnormalities were noted at necropsy. Conclusion: The acute oral median lethal dose (LD5o) of the test item in the female Wistar strain rat was found to be greater than 4040 mg/kg bodyweight (equivalent to 2000 mg active ingredient/kg bodyweight). |
| Report Number | Project Number: 41104687 |
| Url | https://chemview.epa.gov/chemview/chemicaldata.do?sourceId=2&templateType=Endpoint&chemicalDataId=31658760&chemicalId=80358&modalVaeKey=0-0-2-0 |
| Is Certified Translation | No |
| Dupe Override | No |
| Number Of Pages | 17 |
| Is Public | Yes |
| Language Text | English |