Synthesis and preliminary biological evaluation of a technetium-99m labeled thymidine analog
Lu, CX; Wang, ZWu; Jiang, QFu; Tang, Jie; Tan, C; Zhang, JK
| HERO ID | 4850278 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | Synthesis and preliminary biological evaluation of a technetium-99m labeled thymidine analog |
| Authors | Lu, CX; Wang, ZWu; Jiang, QFu; Tang, Jie; Tan, C; Zhang, JK |
| Journal | Chinese Chemical Letters |
| Volume | 22 |
| Issue | 11 |
| Page Numbers | 1309-1312 |
| Abstract | The synthesis and labeling of (99m)Tc-N(3)-{N'-[2-sulfanyl-ethylamino)acetyl]-2-aminoethyl-sulfanyl-1-hexanamide]thymidine ((99m)Tc-NHT) were studied. In the presence of sodium glucoheptonate (GH) and ethylene diamine tetraacetic acid (EDTA), (99m)Tc-NHT was obtained by using bisaminoethanethiol (N(2)S(2)) as a bifunctional coupling agent. The radiochemical purity of the (99m)Tc-NHT was over 95%. Biodistribution of (99m)Tc-NHT was performed in hepatoma HepA tumor-bearing mice. At 2 h p.i., the ratios of tumor-to-muscle, tumor-to-bone and tumor-to-blood were 4.41 +/- 0.32, 2.45 +/- 0.24 and 1.51 +/- 0.18, respectively. (C) 2011 Chun Xiong Lu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| Doi | 10.1016/j.cclet.2011.06.012 |
| Wosid | WOS:000296223400013 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Synthesis; (99m)Tc-NHT; Biodistribution; Thymidine analog; Tumor imaging |