Preparation and preliminary biological evaluation of novel (99m)Tc-labelled thymidine analogs as tumor imaging agents
Lu, C; Jiang, Q; Tan, C; Tang, J; Zhang, J
| HERO ID | 4850114 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Preparation and preliminary biological evaluation of novel (99m)Tc-labelled thymidine analogs as tumor imaging agents |
| Authors | Lu, C; Jiang, Q; Tan, C; Tang, J; Zhang, J |
| Journal | Molecules |
| Volume | 17 |
| Issue | 7 |
| Page Numbers | 8518-8532 |
| Abstract | Two kinds of novel thymidine derivatives, N-thymidine-yl-N′-methyl-N′-{N′′-[2-sulfanyl-(ethylamino)acetyl]-2-aminoethylsulfanyl-1-hexanamide}-ethanediamine (TMHEA) and N-thymidine-yl-N′-methyl-N′-{N′′-[2-sulfanyl-(ethylamino)acetyl]-2-aminoethylsulfanyl-1-hexanamide}-hexanediamine (TMHHA) were prepared and successfully labeled with (99m)Tc in high labeling yields. The in vitro stability and in vivo biodistribution of (99m)Tc-TMHEA and (99m)Tc-TMHHA were investigated and compared. The biodistribution studies indicate that the radiotracer (99m)Tc-TMHEA displays selective tumor uptake, suggesting it is a potential tumor imaging agent. |
| Doi | 10.3390/molecules17078518 |
| Pmid | 22801365 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |