Evaluation of human major histocompatibility complex class I chain-related A as a potential target for tumor imaging
Tang, B; Yang, Z; Huang, J; Hao, Z; Li, W; Cui, L; He, W
| HERO ID | 4850090 |
|---|---|
| In Press | No |
| Year | 2008 |
| Title | Evaluation of human major histocompatibility complex class I chain-related A as a potential target for tumor imaging |
| Authors | Tang, B; Yang, Z; Huang, J; Hao, Z; Li, W; Cui, L; He, W |
| Journal | Cancer Letters |
| Volume | 263 |
| Issue | 1 |
| Page Numbers | 99-106 |
| Abstract | To investigate the feasibility of using human major histocompatibility complex class I chain-related A (MICA) as a target for tumor imaging diagnosis, 10C6, a monoclonal antibody (mAb) that specifically recognizes MICA in vitro, was labeled with (99m)Tc (technetium) and administered into mice bearing MICA-positive human ovarian epithelial carcinoma line SKOV3. Measurement of organ-specific radioactivity showed that tumor accumulated radioactivity continuously, while the uptake in the other organs decreased over time. Scintigram showed that the tumor became clearly visible at 24h post-injection of radio-labeled 10C6 mAb. These results suggest that MICA is a promising target for tumor imaging and mAb 10C6 may be used clinically for early tumor diagnosis. |
| Doi | 10.1016/j.canlet.2007.12.027 |
| Pmid | 18249063 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |