Circumvention of pH dependent release from ethylcellulose-coated pellets
Dressman, JB; Derbin, GM; Ismailos, G; Jarvis, C; Wheatley, TA; Et al
| HERO ID | 4829096 |
|---|---|
| In Press | No |
| Year | 1995 |
| Title | Circumvention of pH dependent release from ethylcellulose-coated pellets |
| Authors | Dressman, JB; Derbin, GM; Ismailos, G; Jarvis, C; Wheatley, TA; Et al |
| Journal | Journal of Controlled Release |
| Volume | 36 |
| Issue | Oct 1995 |
| Abstract | IPA COPYRIGHT: ASHP To investigate the source of pH dependency of release from ethylcellulose (Aquacoat)-coated pellets, phenylpropanolamine hydrochloride pellets overcoated with ethylcellulose were examined. pH dependency of release was observed in all batches plasticized with dibutyl sebacate and column dried to an end-product temperature of 43-45DGC. However, when batches were heated for an additional 2 h in a forced air oven, or triethyl citrate was used as plasticizer, release was virtually independent of pH. Heating the product above the glass transition temperature (Tg) of the plasticized film was associated with more consistent release profiles. Contact angle measurements suggested that these effects were associated with changes in surface behavior upon heating; little change in titration data was seen. It was hypothesized that heating the product above the Tg of the plasticized film results in film relaxation, enabling even distribution of the surfactant throughout the film and thus minimizing surface effects that are associated with pH dependent release. |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |