Association between urinary lead and bone health in a general population from Taiwan
Tsai, TL; Pan, WH; Chung, YT; Wu, TN; Tseng, YC; Liou, SH; Wang, SL
HERO ID
4666947
Reference Type
Journal Article
Year
2016
Language
English
PMID
| HERO ID | 4666947 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Association between urinary lead and bone health in a general population from Taiwan |
| Authors | Tsai, TL; Pan, WH; Chung, YT; Wu, TN; Tseng, YC; Liou, SH; Wang, SL |
| Journal | Journal of Exposure Science & Environmental Epidemiology |
| Volume | 26 |
| Issue | 5 |
| Page Numbers | 481-487 |
| Abstract | Lead accumulates in adult bones for many decades; previous studies have shown lead's detrimental effects on osteoblast and osteoclast activity in association with bone remodeling. Osteoporosis is a disease of the bones resulting in low bone mass that induces fragile bones and hence susceptibility of fracture. We estimated the association between urinary lead (U-Pb) levels and bone health in adults participating in the third Nutrition and Health Survey in Taiwan (NAHSIT) from 2005 to 2008. A total of 398 participants were divided into normal (T-score>-1), osteopenic (T-score between -1 and -2.5), or osteoporotic (T-score<-2.5) groups according to the results of bone mineral density (BMD) measurements. Heavy metals were measured in urine specimens using inductively coupled plasma-mass spectrometry. In the multivariable logistic regression analysis, age (OR=1.08; 95% CI=1.05-1.10), former smokers (OR=2.95; 95% CI=1.22-7.11) and higher U-Pb levels than upper tertile (OR=2.30; 95% CI=1.19-4.48) were associated with osteopenia/osteoporosis. Furthermore, age (OR=1.06; 95% CI=1.02-1.10) and higher U-Pb levels (OR=2.81; 95% CI=1.13-6.97) were significantly associated with osteopenia and osteoporosis in women. These results suggest that adults, particularly in women, with higher U-Pb levels may have increased odds of osteopenia and osteoporosis. |
| Doi | 10.1038/jes.2015.30 |
| Pmid | 26152405 |
| Wosid | WOS:000381780500007 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | bone mineral density; cigarette smoking; lead; osteopenia; osteoporosis |
| Is Peer Review | Yes |
| Relationship(s) |
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