Relationship between perinatal antioxidant vitamin and heavy metal levels and the growth and cognitive development of children at 5 years of age
Liu, YF; Chen, Q; Wei, XP; Chen, L; Zhang, X; Chen, K; Chen, J; Li, TY
HERO ID
4642606
Reference Type
Journal Article
Year
2015
Language
English
PMID
| HERO ID | 4642606 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | Relationship between perinatal antioxidant vitamin and heavy metal levels and the growth and cognitive development of children at 5 years of age |
| Authors | Liu, YF; Chen, Q; Wei, XP; Chen, L; Zhang, X; Chen, K; Chen, J; Li, TY |
| Journal | Asia Pacific Journal of Clinical Nutrition |
| Volume | 24 |
| Issue | 4 |
| Page Numbers | 650-658 |
| Abstract | To evaluate how prenatal exposure to antioxidant vitamins and heavy metals affects subsequent development. Maternal serum and cord serum levels of antioxidant vitamins (A, E, and C) were determined. Full-state, performance, and verbal intelligence quotients (FSIQ, PIQ, and VIQ, respectively) of 97 children were assessed at 5 years of age. The placental transport ratio (PTR: cord level relative to maternal serum level) of vitamin A (VA) was associated positively with FSIQ score (p=0.041), vitamin E (VE)-PTR was associated positively with PIQ (p=0.002) and FSIQ (p=0.025) scores, and cord serum cadmium (Cd) level was correlated negatively with VIQ score (p=0.025) at 5 years of age. High VE-PTR protected against low PIQ (OR=0.025; p=0.021) and FSIQ (OR<0.001; p=0.004). High maternal age was a protective factor against low VIQ (OR=0.661; 95% CI, 0.500- 0.875; p=0.004) and FSIQ (OR=0.700; 95% CI, 0.512-0.957; p=0.025). A higher maternal education (OR=0.038; 95% CI, 0.003-0.458; p=0.010) and economic level (OR=0.047; 95% CI, 0.004-0.579; p=0.017) were protective against a low FSIQ score. VA-PTR predicted physical growth. VA-PTR and VE-PTR predicted intelligence test performance at 5 years old. High Cd in cord blood may negatively affect subsequent intelligence. |
| Doi | 10.6133/apjcn.2015.24.4.25 |
| Pmid | 26693750 |
| Wosid | WOS:000368049500012 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | antioxidant vitamins; heavy metals; intelligence quotients; cord blood; children |
| Is Peer Review | Yes |
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