Toxicity of Glutathione-Binding Metals: A Review of Targets and Mechanisms
Rubino, FM
HERO ID
4642511
Reference Type
Journal Article
Subtype
Review
Year
2015
Language
English
PMID
| HERO ID | 4642511 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2015 |
| Title | Toxicity of Glutathione-Binding Metals: A Review of Targets and Mechanisms |
| Authors | Rubino, FM |
| Journal | Toxics |
| Volume | 3 |
| Issue | 1 |
| Page Numbers | 20-62 |
| Abstract | Mercury, cadmium, arsenic and lead are among priority metals for toxicological studies due to the frequent human exposure and to the significant burden of disease following acute and chronic intoxication. Among their common characteristics is chemical affinity to proteins and non-protein thiols and their ability to generate cellular oxidative stress by the best-known Fenton mechanism. Their health effects are however diverse: kidney and liver damage, cancer at specific sites, irreversible neurological damages with metal-specific features. Mechanisms for the induction of oxidative stress by interaction with the cell thiolome will be presented, based on literature evidence and of experimental findings. |
| Doi | 10.3390/toxics3010020 |
| Pmid | 29056650 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | arsenic; cadmium; EdAG; enzymes; glutathione; lead; mass spectrometry; mechanism; metallothionein; mercury; nanoparticles |
| Is Peer Review | Yes |