The activator protein-1 transcription factor in respiratory epithelium carcinogenesis
Karamouzis, MV; Konstantinopoulos, PA; Papavassiliou, AG
HERO ID
4570445
Reference Type
Journal Article
Subtype
Review
Year
2007
Language
English
PMID
| HERO ID | 4570445 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2007 |
| Title | The activator protein-1 transcription factor in respiratory epithelium carcinogenesis |
| Authors | Karamouzis, MV; Konstantinopoulos, PA; Papavassiliou, AG |
| Journal | Molecular Cancer Research |
| Volume | 5 |
| Issue | 2 |
| Page Numbers | 109-120 |
| Abstract | Respiratory epithelium cancers are the leading cause of cancer-related death worldwide. The multistep natural history of carcinogenesis can be considered as a gradual accumulation of genetic and epigenetic aberrations, resulting in the deregulation of cellular homeostasis. Growing evidence suggests that cross-talk between membrane and nuclear receptor signaling pathways along with the activator protein-1 (AP-1) cascade and its cofactor network represent a pivotal molecular circuitry participating directly or indirectly in respiratory epithelium carcinogenesis. The crucial role of AP-1 transcription factor renders it an appealing target of future nuclear-directed anticancer therapeutic and chemoprevention approaches. In the present review, we will summarize the current knowledge regarding the implication of AP-1 proteins in respiratory epithelium carcinogenesis, highlight the ongoing research, and consider the future perspectives of their potential therapeutic interest. |
| Doi | 10.1158/1541-7786.MCR-06-0311 |
| Pmid | 17314269 |
| Wosid | WOS:000244538200001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |