Antinociceptive and anti-inflammatory effects of the aerial parts of Artemisia dracunculus in mice
Eidi, A; Oryan, S; Zaringhalam, J; Rad, M
| HERO ID | 4475050 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Antinociceptive and anti-inflammatory effects of the aerial parts of Artemisia dracunculus in mice |
| Authors | Eidi, A; Oryan, S; Zaringhalam, J; Rad, M |
| Journal | Pharmaceutical Biology |
| Volume | 54 |
| Issue | 3 |
| Page Numbers | 549-554 |
| Abstract | <strong>CONTEXT: </strong>Tarragon (Artemisia dracunculus L., Asteraceae) is an ancient herb, which is widely used as a medicine, flavoring, or fragrance.<br /><br /><strong>OBJECTIVE: </strong>To determine the antinociceptive and anti-inflammatory effects of aerial parts of tarragon, we investigated the effects of ethanolic extract of the plant in adult male Balb/c mice.<br /><br /><strong>MATERIALS AND METHODS: </strong>Antinociceptive activity was determined using formalin, hot-plate, and writhing tests. The effect of the ethanolic extract on acute inflammation was evaluated by xylene-induced ear edema in mice. The ethanolic extract was administered at doses of 5, 10, 50, and 100 mg/kg, i.p. The control group received saline as vehicle of ethanolic extract.<br /><br /><strong>RESULTS: </strong>Our results showed that the ethanolic extract (50 and 100 mg/kg) decreased both phases of pain in the formalin test (ED50 = 109.66 and 87.13 mg/kg, respectively). In the hot-plate test, the extract (50 and 100 mg/kg) increased pain threshold during 60 min (ED50 = 81.03 mg/kg). The extract (50 and 100 mg/kg) exhibited antinociceptive activity against acetic acid-induced writhing (ED50 = 66.99 mg/kg). The extract (50 and 100 mg/kg) showed significant activity in the xylene ear edema test (ED50 = 78.20 mg/kg). Pretreatment of the animals with naloxone decreased the analgesia induced by the extract in hot-plate and formalin tests; therefore, opioid receptors may be involved, at least partly, in the analgesic effect of tarragon extract.<br /><br /><strong>DISCUSSION AND CONCLUSION: </strong>The results suggested that tarragon have significant analgesic and anti-inflammatory effects in mice, and, therefore, further studies are required to evaluate these effects and additional potential of the plant. |
| Doi | 10.3109/13880209.2015.1056312 |
| Pmid | 26079854 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |