Reproductive and developmental toxicity of potassium perfluorohexanesulfonate in CD-1 mice
Chang, S; Butenhoff, JL; Parker, GA; Coder, PS; Zitzow, JD; Krisko, RM; Bjork, JA; Wallace, KB; Seed, JG
HERO ID
4409324
Reference Type
Journal Article
Year
2018
Language
English
PMID
| HERO ID | 4409324 |
|---|---|
| In Press | No |
| Year | 2018 |
| Title | Reproductive and developmental toxicity of potassium perfluorohexanesulfonate in CD-1 mice |
| Authors | Chang, S; Butenhoff, JL; Parker, GA; Coder, PS; Zitzow, JD; Krisko, RM; Bjork, JA; Wallace, KB; Seed, JG |
| Journal | Reproductive Toxicology |
| Volume | 78 |
| Page Numbers | 150-168 |
| Abstract | Potassium perfluorohexanesulfoante (K+PFHxS) was evaluated for reproductive/developmental toxicity in CD-1 mice. Up to 3 mg/kg-d K+PFHxS was administered (n = 30/sex/group) before mating, for at least 42 days in F0 males, and for F0 females, through gestation and lactation. F1 pups were directly dosed with K+PFHxS for 14 days after weaning. There was an equivocal decrease in live litter size at 1 and 3 mg/kg-d, but the pup-born-to-implant ratio was unaffected. Adaptive hepatocellular hypertrophy was observed, and in 3 mg/kg-d F0 males, it was accompanied by concomitant decreased serum cholesterol and increased alkaline phosphatase. There were no other toxicologically significant findings on reproductive parameters, hematology/clinical pathology/TSH, neurobehavioral effects, or histopathology. There were no treatment-related effects on postnatal survival, development, or onset of preputial separation or vaginal opening in F1 mice. Consistent with previous studies, our data suggest that the potency of PFHxS is much lower than PFOS in rodents. |
| Doi | 10.1016/j.reprotox.2018.04.007 |
| Pmid | 29694846 |
| Wosid | WOS:000435227200018 |
| Url | https://search.proquest.com/docview/2031421843?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Reproductive toxicology (Elmsford, N.Y.) ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | Perfluorohexanesulfonate; PFHxS; Reproductive; Developmental; Liver; Cholesterol; Thyroid; Mice |