Synthesis of 1-octadecanol-modified water-swelling polyurethane hydrogels as vaginal drug-delivery vehicle
Yuan, D; Ju, C; Ding, S; Jing, X; Zhang, C
HERO ID
4407501
Reference Type
Journal Article
Year
2010
Language
English
PMID
| HERO ID | 4407501 |
|---|---|
| In Press | No |
| Year | 2010 |
| Title | Synthesis of 1-octadecanol-modified water-swelling polyurethane hydrogels as vaginal drug-delivery vehicle |
| Authors | Yuan, D; Ju, C; Ding, S; Jing, X; Zhang, C |
| Journal | Journal of Biomaterials Science, Polymer Edition |
| Volume | 21 |
| Issue | 4 |
| Page Numbers | 493-505 |
| Abstract | The purpose of this work was to develop a novel polyurethane hydrogel system for sustained drug release, which could be used as a vaginal drug-delivery vehicle. The blank polyurethane hydrogels were synthesized by a polyol oligomeric, a diisocyanate and a triol (used as cross-linking agent). In order to improve the swelling ability of a polyurethane hydrogel, a small amount of 1-octadecanol was added. Additionally, the structure, mechanical properties and thermal properties of polymers were assessed by FT-IR, WAXD, DSC and mechanical tests. The results show that no more than 2.5 wt% of 1-octadecanol additives is sufficient to affect the release profile without changing the structure and mechanical properties of the polyurethane hydrogels obviously. Tinidazole was chosen as a model drug, the release data of drug from polyurethane hydrogels were fitted using the Ritger-Peppas equation and the result showed that it was non-Fickian diffusion, which means that the drug release was controlled by both swollen control and diffusion control. In conclusion, our work proves that the synthesized polyurethane hydrogel modified by 1-octadecanol may be a promising sustained release drug carrier. |
| Doi | 10.1163/156856209X427032 |
| Pmid | 20233505 |
| Wosid | WOS:000275981600006 |
| Is Certified Translation | No |
| Dupe Override | Yes |
| Is Public | Yes |
| Language Text | English |
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