DuPont-24030: FRD-902: Acute dermal irritation study in rabbits
Carpenter, C
HERO ID
4353918
Reference Type
Technical Report
Subtype
EPA Report
Year
2007
Language
English
| HERO ID | 4353918 |
|---|---|
| Material Type | EPA Report |
| Year | 2007 |
| Title | DuPont-24030: FRD-902: Acute dermal irritation study in rabbits |
| Authors | Carpenter, C |
| Publisher Text | E.I. du Pont de Nemours and Company |
| City | Wilmington, Delaware |
| Abstract | FRD-902 was applied as a single 0.5-mL dermal dose to the shaved intact skin of a single New Zealand White rabbit. Since no corrosion occurred, 2 additional rabbits were treated. The test substance was applied to a 6 cm² area of skin. The application area was covered with a 2-ply gauze square which was held in place with non-irritating tape and covered with porous tape for a semi-occlusive dressing. The rabbits were exposed to the test substance for 4 hours after which the test substance was removed. Test sites were evaluated and scored by the method of Draize for signs of dermal irritation approximately 60 minutes, and 24, 48/50, and 72 hours after test substance removal. The rabbit that was initially treated was also examined immediately after test substance removal. Erythema (score of 1 or 2) but no edema was observed in the 3 rabbits on the day of dosing. No dermal irritation was observed at 24, 48/50, or 72 hours after removal of the test substance. No clinical signs were observed, and no body weight loss occurred. Under the conditions of this study, FRD-902 produced erythema, which cleared by 24 hours, when applied to the skin of rabbits. In accordance with the provisions of Directive 67/548/EEC, classification is not required based on the results of this study. |
| Is Certified Translation | No |
| Dupe Override | No |
| Number Of Pages | 20 |
| Comments | Associated report numbers: DuPont-24030 US EPA OPPTS 870.2500 OECD Guideline 404 |
| Is Public | Yes |
| Language Text | English |
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