Correlation of data from the strain A mouse bioassay with long-term bioassays
Maronpot, RR
HERO ID
43306
Reference Type
Journal Article
Year
1991
Language
English
PMID
| HERO ID | 43306 |
|---|---|
| In Press | No |
| Year | 1991 |
| Title | Correlation of data from the strain A mouse bioassay with long-term bioassays |
| Authors | Maronpot, RR |
| Journal | Experimental Lung Research |
| Volume | 17 |
| Issue | 2 |
| Page Numbers | 425-431 |
| Abstract | Fifty-nine chemicals that had completed National Cancer Institute rat and mouse 2-year carcinogenicity tests were tested in the strain A mouse pulmonary tumor assay. Without knowledge of chemical identity, 53 chemicals were tested in strain A mice in one laboratory and 30 were tested in a second independent laboratory. Strain A tests on 24 of these chemicals were conducted in both laboratories. The strain A results were generally not predictive of the 2-year rat and mouse carcinogenicity test results. Furthermore, there was poor agreement of strain A results between the two laboratories. Although a variety of explanations may be invoked to explain the lack of concordance between the strain A tests and the 2-year rat and mouse tests, no one factor is sufficient to rationalize the poor concordance between strain A and 2-year carcinogenicity bioassay results. |
| Doi | 10.3109/01902149109064429 |
| Pmid | 2050041 |
| Wosid | WOS:A1991FC88200026 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Research Triangle Park, NC |
| Conference Name | Symposium on Mouse Pulmonary Carcinogenesis, to honor the memory of Dr Michael B Shimkin Research |
| Conference Date | March 27-28, 1990 |
| Comments | Exp. Lung Res. 17: 425-431. |
| Is Public | Yes |
| Language Text | English |