Associations between urinary total arsenic levels, fetal development, and neonatal birth outcomes: A cohort study in Taiwan
Liao, KW; Chang, CH; Tsai, MS; Chien, LC; Chung, MY; Mao, IF; Tsai, YA; Chen, ML
HERO ID
4242606
Reference Type
Journal Article
Year
2018
Language
English
PMID
| HERO ID | 4242606 |
|---|---|
| In Press | No |
| Year | 2018 |
| Title | Associations between urinary total arsenic levels, fetal development, and neonatal birth outcomes: A cohort study in Taiwan |
| Authors | Liao, KW; Chang, CH; Tsai, MS; Chien, LC; Chung, MY; Mao, IF; Tsai, YA; Chen, ML |
| Journal | Science of the Total Environment |
| Volume | 612 |
| Page Numbers | 1373-1379 |
| Abstract | <strong>BACKGROUND: </strong>Arsenic exposure is a global health concern. Several studies have focused on chronic arsenic exposure in adults; however, limited data are available regarding the potential adverse effects of prenatal exposure on fetuses and neonates.<br /><br /><strong>OBJECTIVES: </strong>To assess which time point maternal arsenic exposure may influence the fetus during pregnancy and birth outcomes.<br /><br /><strong>METHODS: </strong>In this study, total arsenic concentrations were analyzed in urine samples collected from 130 women with singleton pregnancies (22-45years old) in Taiwan from March to December of 2010. All fetal biometric measurements in each trimester period and birth outcomes at delivery were obtained. We applied a generalized estimating equation model and multivariate regression models to evaluate the associations between maternal urinary total arsenic (UtAs) exposure during pregnancy, fetal biometric measurements, and neonatal birth outcomes.<br /><br /><strong>RESULTS: </strong>We observed statistically significant correlations between maternal UtAs levels and the fetal biparietal diameter over all three trimesters (β=-1.046mm, p<0.05). Multiple regression analyses showed a negative association between maternal UtAs levels and chest circumference in the first trimester (β=-0.721cm, p<0.05), and second-trimester UtAs exposure was associated with decreases in birth weight (β=-173.26g, p<0.01), head circumference (β=-0.611cm, p<0.05), and chest circumference (β=-0.654cm, p<0.05). Dose-response relationships were also observed for maternal UtAs exposure and birth outcomes.<br /><br /><strong>CONCLUSIONS: </strong>We identified a negative relationship between maternal UtAs levels during pregnancy, fetal development, and neonatal birth outcomes. These findings should be confirmed in future studies with large sample sizes. |
| Doi | 10.1016/j.scitotenv.2017.08.312 |
| Pmid | 28898944 |
| Wosid | WOS:000413313700135 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |