Taurine ameliorates arsenic-induced apoptosis in the hippocampus of mice through intrinsic pathway
Li, S; Yang, L; Zhang, Y; Zhang, C; Shao, J; Liu, X; Li, Y; Piao, F
HERO ID
4242591
Reference Type
Book/Book Chapter
Year
2017
Language
English
PMID
| HERO ID | 4242591 |
|---|---|
| Year | 2017 |
| Title | Taurine ameliorates arsenic-induced apoptosis in the hippocampus of mice through intrinsic pathway |
| Book Title | Taurine 10 |
| Authors | Li, S; Yang, L; Zhang, Y; Zhang, C; Shao, J; Liu, X; Li, Y; Piao, F |
| Editor | Lee, DH; Schaffer, SW; Park, E; Kim, HW |
| Publisher Text | Springer |
| City | Dordrecht, Netherlands |
| Page Numbers | 183-192 |
| Abstract | Our group previously reported that arsenic (As) exposure induced apoptosis in hippocampus neurons. The aim of the present study was to clarify the protective capacity of taurine (Tau) on As-induced neuronal apoptosis and the related mechanism in mouse hippocampus. Mice were divided into: control group, Tau control group, As exposure group and Tau protective group, randomly. The apoptotic rate of mouse hippocampus was determined by TUNEL staining. The levels of Bcl-2 and Bax gene and protein were analyzed by real time RT-PCR and WB, respectively. Furthermore, cytochrome c (Cyt C) release, and the activity of caspase-8 and caspase-3 were also determined. The results showed that Tau treatment induced the decrease of TUNEL-positive cells, prohibited the disturbance of Bcl-2 and Bax expression, and inhibited Cyt C release and caspase-8 and caspase-3 activation significantly. The results indicated that Tau supplement markedly ameliorates As-induced apoptosis by mitochondria-related pathway in mouse hippocampus. |
| Doi | 10.1007/978-94-024-1079-2_16 |
| Pmid | 28849454 |
| Wosid | WOS:000428231500016 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Seoul, South Korea |
| Series | Advances in Experimental Medicine and Biology, vol. 975 |
| Isbn | 9789402410778 |
| Conference Name | 20th International Taurine Meeting |
| Conference Date | May 23-27, 2016 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Arsenic; Taurine; Apoptosis; Hippocampus; Intrinsic pathway |