Rice consumption and squamous cell carcinoma of the skin in a United States population
Gossai, A; Zens, MS; Punshon, T; Jackson, BP; Perry, AE; Karagas, MR
HERO ID
4242559
Reference Type
Journal Article
Year
2017
Language
English
PMID
| HERO ID | 4242559 |
|---|---|
| In Press | No |
| Year | 2017 |
| Title | Rice consumption and squamous cell carcinoma of the skin in a United States population |
| Authors | Gossai, A; Zens, MS; Punshon, T; Jackson, BP; Perry, AE; Karagas, MR |
| Journal | Environmental Health Perspectives |
| Volume | 125 |
| Issue | 9 |
| Page Numbers | 097005 |
| Abstract | <strong>BACKGROUND: </strong>Rice contains arsenic, a known skin carcinogen. Rice intake has been associated with arsenic-related skin lesions in South Asia, but its association with skin cancers is as yet unknown.<br /><br /><strong>OBJECTIVES: </strong>We aimed to investigate whether rice intake contributes to urinary arsenic concentration and risk of squamous cell carcinoma (SCC) of the skin in a U.S. population.<br /><br /><strong>METHODS: </strong>Rice consumption was assessed using a food frequency questionnaire administered as part of a population-based case-control study of 487 SCC cases and 462 age- and gender-matched controls. Arsenic concentration in household tap water and urine samples were measured using inductively coupled mass spectrometry (ICP-MS) and high-resolution ICP-MS, respectively. Odds ratios (OR) for SCC associated with the frequency of rice consumption were estimated using logistic regression, with adjustment for age, gender, and caloric intake.<br /><br /><strong>RESULTS: </strong>Those who reported any rice consumption had higher urinary arsenic concentrations than those who did not consume rice, and the association was most pronounced among those with <1μg/L arsenic in their household water (19.2% increase in total urinary arsenic, 95% CI: 5.0, 35.3%). Any rice consumption was associated with a 1.5-fold (95% CI: 1.1, 2.0) higher odds of SCC compared with those who reported no rice consumption, and the relation appeared to be largely among those with <1μg/L water arsenic.<br /><br /><strong>CONCLUSION: </strong>Rice consumption may be related to the occurrence of SCC in the United States, especially among those with relatively low drinking water arsenic exposure. https://doi.org/10.1289/EHP1065. |
| Doi | 10.1289/EHP1065 |
| Pmid | 28934722 |
| Wosid | WOS:000413792800015 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |