Activation of liver X receptors promotes inflammatory cytokine mRNA degradation by upregulation of tristetraprolin
Xiao, J; Chen, Q; Tang, D; Ou, W; Wang, J; Mo, Z; Tang, C; Peng, L; Wang, D
| HERO ID | 4239762 |
|---|---|
| In Press | No |
| Year | 2017 |
| Title | Activation of liver X receptors promotes inflammatory cytokine mRNA degradation by upregulation of tristetraprolin |
| Authors | Xiao, J; Chen, Q; Tang, D; Ou, W; Wang, J; Mo, Z; Tang, C; Peng, L; Wang, D |
| Journal | Acta Biochimica et Biophysica Sinica |
| Volume | 49 |
| Issue | 3 |
| Page Numbers | 277-283 |
| Abstract | Liver X receptors (LXRs) have anti-inflammatory properties. Whether LXRs play a role in post-transcriptional control of inflammatory cytokine expression is not clear. Here, we firstly identified that the synthetic LXR agonist T0901317 promoted IL-1β, IL-6 and TNFα mRNA degradation. Moreover, T0901317 destabilized TNFα mRNA through its 3'-untranslated region. In addition, T0901317 increased the expression of tristetraprolin (TTP), while antagonizing TTP with siRNA abrogated T0901317-mediated inflammatory cytokine mRNA decay. Interestingly, T0901317 repressed LPS-induced phosphorylation of ERK1/2 and p38 mitogen-activated protein kinase (MAPK) in THP-1 macrophages. The evidence presented here confirms that LXR activation with T0901317 inhibits the phosphorylation of ERK1/2 and p38 MAPK, likely resulting in the increased expression of TTP and the decay of LPS-induce inflammatory cytokine mRNAs. |
| Doi | 10.1093/abbs/gmw136 |
| Pmid | 28119310 |
| Wosid | WOS:000397089800010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | liver X receptor; cytokine; mRNA decay; tristetraprolin; mitogen-activated protein kinase |