An immobilized liquid interface prevents device associated bacterial infection in vivo
Chen, J; Howell, C; Haller, CA; Patel, MS; Ayala, P; Moravec, KA; Dai, E; Liu, L; Sotiri, I; Aizenberg, M; Aizenberg, J; Chaikof, EL
| HERO ID | 4239640 |
|---|---|
| In Press | No |
| Year | 2017 |
| Title | An immobilized liquid interface prevents device associated bacterial infection in vivo |
| Authors | Chen, J; Howell, C; Haller, CA; Patel, MS; Ayala, P; Moravec, KA; Dai, E; Liu, L; Sotiri, I; Aizenberg, M; Aizenberg, J; Chaikof, EL |
| Journal | Biomaterials |
| Volume | 113 |
| Page Numbers | 80-92 |
| Abstract | Virtually all biomaterials are susceptible to biofilm formation and, as a consequence, device-associated infection. The concept of an immobilized liquid surface, termed slippery liquid-infused porous surfaces (SLIPS), represents a new framework for creating a stable, dynamic, omniphobic surface that displays ultralow adhesion and limits bacterial biofilm formation. A widely used biomaterial in clinical care, expanded polytetrafluoroethylene (ePTFE), infused with various perfluorocarbon liquids generated SLIPS surfaces that exhibited a 99% reduction in S. aureus adhesion with preservation of macrophage viability, phagocytosis, and bactericidal function. Notably, SLIPS modification of ePTFE prevents device infection after S. aureus challenge in vivo, while eliciting a significantly attenuated innate immune response. SLIPS-modified implants also decrease macrophage inflammatory cytokine expression in vitro, which likely contributed to the presence of a thinner fibrous capsule in the absence of bacterial challenge. SLIPS is an easily implementable technology that provides a promising approach to substantially reduce the risk of device infection and associated patient morbidity, as well as health care costs. |
| Doi | 10.1016/j.biomaterials.2016.09.028 |
| Pmid | 27810644 |
| Wosid | WOS:000389396300007 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |