Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates
Mahmoud, S; Li, H; Mcbrayer, TR; Bassit, L; Hammad, SF; Coats, SJ; Amblard, F; Schinazi, RF
| HERO ID | 4239070 |
|---|---|
| In Press | No |
| Year | 2017 |
| Title | Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates |
| Authors | Mahmoud, S; Li, H; Mcbrayer, TR; Bassit, L; Hammad, SF; Coats, SJ; Amblard, F; Schinazi, RF |
| Journal | Nucleosides, Nucleotides and Nucleic Acids |
| Volume | 36 |
| Issue | 1 |
| Page Numbers | 66-82 |
| Abstract | A novel series of tetrafluoro and hexafluoro acyclic nucleosides and their phosphoramidates were successfully prepared from commercially available 2,2,3,3-tetrafluoro-1,4-butanediol and 2,2,3,3,4,4-hexafluoro-1,5-pentanediol in four to six steps. Their ability to block HIV, HCV, HSV-1, and HBV replication along with their cytotoxicity toward HepG2, human lymphocyte, CEM, and Vero cells was assessed. |
| Doi | 10.1080/15257770.2016.1218023 |
| Pmid | 27759481 |
| Wosid | WOS:000392248000005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Fluorine; acyclonucleoside; phosphoramidates; antiviral agent |