Hydroxylated polychlorinated biphenyl metabolites (OH-PCBs), maternal smoking and size at birth
Kezios, K; Gu, Y; Liu, X; Cirillo, P; Tarrant, D; Petreas, M; Park, JS; Cohn, B; Factor-Litvak, P
HERO ID
3982756
Reference Type
Journal Article
Year
2017
Language
English
PMID
| HERO ID | 3982756 |
|---|---|
| In Press | No |
| Year | 2017 |
| Title | Hydroxylated polychlorinated biphenyl metabolites (OH-PCBs), maternal smoking and size at birth |
| Authors | Kezios, K; Gu, Y; Liu, X; Cirillo, P; Tarrant, D; Petreas, M; Park, JS; Cohn, B; Factor-Litvak, P |
| Journal | Reproductive Toxicology |
| Volume | 71 |
| Page Numbers | 166-175 |
| Abstract | In a sample of 442 births from the Child Health and Development Studies cohort, we examined associations between maternal prenatal exposure to hydroxylated polychlorinated biphenyl metabolites (OH-PCBs) and pregnancy outcomes, and whether associations were mediated by maternal thyroid hormone levels and/or modified by maternal smoking. Compared to nonsmokers, smokers had twice the mean concentration of 4-OH-CB107 (p<0.001) and lower levels of its parent compound, PCB118 (p=0.001). Among mothers who smoked, the birth weight of newborns with maternal concentrations of 4-OH-CB107 in the upper quartile was 316g lighter (95% confidence interval (CI) 566, 65) compared to those with maternal concentrations in the lowest quartile, after control for PCB118 and other potential confounders. This association was not observed for non-smoking mothers and was not mediated by maternal thyroid hormone levels. Maternal prenatal 4-OH-CB107 levels appear to be influenced by maternal smoking and contribute to lower birth weight among smokers. |
| Doi | 10.1016/j.reprotox.2017.02.015 |
| Pmid | 28314564 |
| Wosid | WOS:000406736600026 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |