Long-term PM2.5 exposures and respiratory, cancer and cardiovascular mortality in American older adults
Pun, VC; Kazemiparkouhi, F; Manjourides, J; Suh, HH
HERO ID
3862719
Reference Type
Journal Article
Year
2017
Language
English
PMID
| HERO ID | 3862719 |
|---|---|
| In Press | No |
| Year | 2017 |
| Title | Long-term PM2.5 exposures and respiratory, cancer and cardiovascular mortality in American older adults |
| Authors | Pun, VC; Kazemiparkouhi, F; Manjourides, J; Suh, HH |
| Journal | American Journal of Epidemiology |
| Volume | 186 |
| Issue | 8 |
| Page Numbers | 961-969 |
| Abstract | The impact of chronic exposure to fine particulate matter (PM2.5) on respiratory disease and lung cancer mortality is poorly understood. In a cohort of 18.9 million Medicare beneficiaries (4.2 million deaths) living across the conterminous United States between 2000 to 2008, we examined the association of chronic PM2.5 exposure and cause-specific mortality, and evaluated confounding through adjustment of neighborhood behavioral covariates and decomposition of PM2.5 into two spatiotemporal scales. We found significantly positive associations of 12-month moving average PM2.5 exposures (per 10 ug/m3 increase) with respiratory, chronic obstructive pulmonary disease and pneumonia mortality, with risk ratios ranging from 1.10 to 1.24. We also found significant PM2.5-associated elevated risks for cardiovascular-related and lung cancer mortality. Risk ratios generally increased with longer moving averages; e.g., elevation in 60-month moving averaged PM2.5 exposures was linked to 1.33 times the lung cancer mortality risk (95% confidence interval: 1.24, 1.40), as compared to 1.13 (95% confidence interval: 1.11, 1.15) for 12-month moving averaged exposures. Observed associations were robust in multivariable models, although evidence of unmeasured confounding remained. In our large cohort of American elderly, we provide important new evidence that long-term PM2.5 exposure is significantly related to increased respiratory-, lung cancer and cardiovascular-related mortality. |
| Doi | 10.1093/aje/kwx166 |
| Pmid | 28541385 |
| Wosid | WOS:000412798300009 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |