Polar stir bars for isolation and preconcentration of perfluoroalkyl substances from human milk samples prior to UHPLC-MS/MS analysis
Martín, J; Rodríguez-Gómez, R; Zafra-Gómez, A; Alonso, E; Vílchez, JL; Navalón, A
HERO ID
3859942
Reference Type
Journal Article
Year
2016
Language
English
PMID
| HERO ID | 3859942 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Polar stir bars for isolation and preconcentration of perfluoroalkyl substances from human milk samples prior to UHPLC-MS/MS analysis |
| Authors | Martín, J; Rodríguez-Gómez, R; Zafra-Gómez, A; Alonso, E; Vílchez, JL; Navalón, A |
| Journal | Bioanalysis |
| Volume | 8 |
| Issue | 7 |
| Page Numbers | 633-647 |
| Abstract | <strong>BACKGROUND: </strong>A new method for the determination of four perfluoroalkyl carboxylic acids (from C5 to C8) and perfluorooctane sulfonate in human milk samples using stir-bar sorptive extraction-ultra-HPLC-MS/MS has been accurately optimized and validated.<br /><br /><strong>METHODOLOGY: </strong>Polydimethylsiloxane and polyethyleneglycol modified silicone materials were evaluated.<br /><br /><strong>DISCUSSION: </strong>Overall, polyethyleneglycol led to a better sensitivity. After optimizing experimental variables, the method was validated reaching detection limits in the range of 0.05-0.20 ng ml(-1); recovery rates from 81 to 105% and relative standard deviations fewer than 13% in all cases. The method was applied to milk samples from five randomly selected women. All samples were positive for at least one of the target compounds with concentrations ranging between 0.8 and 6.6 ng ml(-1), being the most abundant perfluorooctane sulfonate. |
| Doi | 10.4155/bio-2015-0009 |
| Pmid | 26978125 |
| Wosid | WOS:000373235500004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962119058&doi=10.4155%2fbio-2015-0009&partnerID=40&md5=4af93428bc94d8a480d0a8efcf9918f8 |
| Is Public | Yes |
| Language Text | English |
| Keyword | endocrine disrupting chemicals; human milk; perfluoroalkyl substances; sample preparation; stir-bar sorptive extraction; UHPLC-MS/MS |
| Is Peer Review | Yes |