Preconception perfluoroalkyl and polyfluoroalkyl substances and incident pregnancy loss, LIFE Study
Louis, GM; Sapra, KJ; Barr, DB; Lu, Z; Sundaram, R
HERO ID
3858527
Reference Type
Journal Article
Year
2016
Language
English
PMID
| HERO ID | 3858527 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Preconception perfluoroalkyl and polyfluoroalkyl substances and incident pregnancy loss, LIFE Study |
| Authors | Louis, GM; Sapra, KJ; Barr, DB; Lu, Z; Sundaram, R |
| Journal | Reproductive Toxicology |
| Volume | 65 |
| Issue | Elsevier |
| Page Numbers | 11-17 |
| Abstract | Equivocal findings are reported for perfluoroalkyl and polyfluoroalkyl substances (PFASs) and self-reported pregnancy loss. We prospectively assessed PFASs and pregnancy loss in a cohort comprising 501 couples recruited preconception and followed daily through 7 post-conception weeks. Seven PFASs were quantified: 2-N-ethyl-perfluorooctane sulfonamide acetate (Et-PFOSA-AcOH); 2-N-methyl-perfluorooctane sulfonamido acetate (Me-PFOSA-AcOH); perfluorodecanoate (PFDeA); perfluorononanoate (PFNA); perfluorooctane sulfonamide (PFOSA); perfluorooctane sulfonate (PFOS); and perfluorooctanoate (PFOA). Women used home pregnancy test kits. Loss denoted conversion from a positive to a negative pregnancy test, onset of menses or clinical confirmation (n=98; 28%). Chemicals were log transformed and rescaled by their standard deviations to estimate adjusted hazard ratios (HRs) and 95% confidence intervals. No significantly elevated HRs were observed for any PFASs suggesting no association with loss: Et-PFOSA-AcOH (1.04; 0.87, 1.23), Me-PFOSA-AcOH (0.79; 0.61, 1.00; p<0.05), PFDeA (0.83; 0.66, 1.04), PFNA (0.86; 0.70, 1.06), PFOSA (0.74; 0.50, 1.09), PFOS (0.81; 0.65, 1.00), and PFOA (0.93; 0.75, 1.16). |
| Doi | 10.1016/j.reprotox.2016.06.011 |
| Pmid | 27319395 |
| Wosid | WOS:000385990900002 |
| Url | https://linkinghub.elsevier.com/retrieve/pii/S0890623816301502 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Cohort; Epidemiology; Miscarriage; Perfluoroalkyl; Perfluoroalkyl acids; Polyfluoroalkyl; Pregnancy loss; Reproductive toxicity |