Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination
Timmermann, CA; Budtz-Jørgensen, E; Jensen, TK; Osuna, CE; Petersen, MS; Steuerwald, U; Nielsen, F; Poulsen, LK; Weihe, P; Grandjean, P
HERO ID
3858497
Reference Type
Journal Article
Year
2017
Language
English
PMID
| HERO ID | 3858497 |
|---|---|
| In Press | No |
| Year | 2017 |
| Title | Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination |
| Authors | Timmermann, CA; Budtz-Jørgensen, E; Jensen, TK; Osuna, CE; Petersen, MS; Steuerwald, U; Nielsen, F; Poulsen, LK; Weihe, P; Grandjean, P |
| Journal | Journal of Immunotoxicology |
| Volume | 14 |
| Issue | 1 |
| Page Numbers | 39-49 |
| Abstract | Perfluoroalkyl substances (PFASs) are highly persistent chemicals that might be associated with asthma and allergy, but the associations remain unclear. Therefore, this study examined whether pre- and postnatal PFAS exposure was associated with childhood asthma and allergy. Measles, mumps, and rubella (MMR) vaccination in early life may have a protective effect against asthma and allergy, and MMR vaccination is therefore taken into account when evaluating these associations. In a cohort of Faroese children whose mothers were recruited during pregnancy, serum concentrations of five PFASs - Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) - were measured at three timepoints (maternal serum in pregnancy week 34-36 and child serum at ages 5 and 13 years) and their association with immunoglobulin E (IgE) (cord blood and at age 7 years) and asthma/allergic diseases (questionnaires at ages 5 and 13 years and skin prick test at age 13 years) was determined. A total of 559 children were included in the analyses. Interactions with MMR vaccination were evaluated. Among 22 MMR-unvaccinated children, higher levels of the five PFASs at age 5 years were associated with increased odds of asthma at ages 5 and 13. The associations were reversed among MMR-vaccinated children. Prenatal PFAS exposure was not associated with childhood asthma or allergic diseases regardless of MMR vaccination status. In conclusion, PFAS exposure at age 5 was associated with increased risk of asthma among a small subgroup of MMR-unvaccinated children but not among MMR-vaccinated children. While PFAS exposure may impact immune system functions, this study suggests that MMR vaccination might be a potential effect-modifier. |
| Doi | 10.1080/1547691X.2016.1254306 |
| Pmid | 28091126 |
| Wosid | WOS:000399597700006 |
| Url | https://search.proquest.com/docview/1861523286?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Allergy; asthma; children; MMR vaccination; perfluoroalkyl substances |