TSCA work plan chemical problem formulation and initial assessment. 1,4-Dioxane
HERO ID
3809027
Reference Type
Technical Report
Year
2015
Language
English
| HERO ID | 3809027 |
|---|---|
| Year | 2015 |
| Title | TSCA work plan chemical problem formulation and initial assessment. 1,4-Dioxane |
| Authoring Organization | U.S. Environmental Protection Agency |
| Publisher Text | Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention |
| City | Washington, DC |
| Abstract | As a part of EPA’s comprehensive approach to enhance the Agency’s management of existing chemicals, in March 2012 EPA/OPPT identified a work plan of chemicals for further assessment under the Toxic Substances Control Act (TSCA)2. After gathering input from stakeholders, EPA/OPPT developed criteria used for identifying chemicals for further assessment3. The criteria focused on chemicals that meet one or more of the following factors: (1) potentially of concern to children’s health (for example, because of reproductive or developmental effects); (2) neurotoxic effects; (3) persistent, bioaccumulative and toxic (PBT); (3) probable or known carcinogens; (4) used in children’s products; or (5) detected in biomonitoring programs. Using this methodology, EPA/OPPT identified a TSCA Work Plan of chemicals as candidates for risk assessment in the next several years. In the prioritization process, 1,4-dioxane was identified for assessment based on classification as a probable human carcinogen, wide use in consumer products, high reported releases to the environment, and presence in groundwater, ambient air and indoor environments. EPA/OPPT is performing risk assessments on chemicals in the work plan. If an assessment identifies unacceptable risks to humans or the environment, EPA will pursue risk management. The target audience for the final risk assessment is primarily EPA risk managers; however, it may also be of interest to the broader risk assessment community as well as US stakeholders interested in 1,4-dioxane. The information presented in the risk assessment may be of assistance to other federal, state and local agencies as well as to members of the general public who are interested in understanding whether there are risks from exposure to 1,4-dioxane. The initial step in the EPA/OPPT risk assessment development process, which is distinct from the initial prioritization exercise, includes planning, scoping and problem formulation. During these steps EPA/OPPT may review currently available data and information, including but not limited to, assessments conducted by others (e.g., authorities in other countries), published or readily available reports and published scientific literature. The problem formulation data review could result in refinement of pathways of interest previously identified in the initial prioritization. This document includes the results of scoping, problem formulation, and initial assessment for 1,4-dioxane. In the scoping stage, EPA/OPPT determined which chemical(s) to include and what uses to consider in the assessment. During problem formulation, EPA/OPPT identified available fate, exposure and hazard data, and characterized potential exposures, receptors and effects. EPA/OPPT developed a conceptual model and an analysis plan as a result of problem formulation. |
| Report Number | 740-R1-5003 |
| Url | http://nepis.epa.gov/Exe/ZyPURL.cgi?Dockey=P100MDC1.TXT |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: ISSN: |
| Is Public | Yes |
| Language Text | English |